Prothrombin G20210A Polymorphism and Thrombophilia
نویسندگان
چکیده
منابع مشابه
Prothrombin G20210A is a bifunctional gene polymorphism.
The G20210A polymorphism has been shown to alter the efficiency of prothrombin mRNA processing. Here we show that the G20210A mutation also alters prothrombin mRNA stability. Three-fold more prothrombin protein and mRNA were produced in NIH-3T3 cells transfected with the prothrombin cDNAs containing the 20210A variant compared to cells expressing the 20210G variant. mRNA stability assays using ...
متن کاملProthrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia.
Risk factors for venous thrombosis in adults are the prothrombin G20210A and the factor V (FV) G1691A mutations and hereditary deficiencies of protein C, protein S and antithrombin. However, data are limited on the relevance of these risk factors for thrombosis in children and adolescents. We therefore investigated 261 patients aged 0 to 18 (median 5.7 years, 48% male) with venous thrombosis an...
متن کاملG20210A prothrombin gene polymorphism and prothrombin activity in subjects with or without angiographically documented coronary artery disease.
BACKGROUND G20210A prothrombin mutation has been associated with high prothrombin levels and an increased risk of venous thrombosis. The role of this common polymorphism, as well as that of prothrombin levels, in determining the risk of arterial disease is still somewhat controversial. METHODS AND RESULTS We determined the prevalence of the G20210A mutation and prothrombin activity in 660 ind...
متن کاملProthrombin gene mutation (G20210A) in healthy Centenarians.
A recently described genetic variant of the prothrombin gene (G to A transition at nucleotide position 20210) is associated with an increased risk of venous thrombosis (1). The 20210A prothrombin allele may precipitate cerebral ischemia or myocardial infarction in young patients with known prothrombotic abnormalities (2, 3). Similarly, it has been demonstrated that factor V Leiden further incre...
متن کامل[A Meta-analysis of prothrombin G20210A polymorphism and its risk for sudden sensorineural hearing loss].
OBJECTIVE To investigate the correlation between prothrombin G20210A polymorphism and the risk for idiopathic sudden sensorineural hearing loss (ISSNHL) using Meta-analysis methodology. METHODS Databases, including PUBMED, EMBASE, Cochrane Library and CBM, were searched to collect the case control studies on the correlation between prothrombin G20210A polymorphism and idiopathic sudden sensor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2000
ISSN: 0025-6196
DOI: 10.4065/75.6.595